genome wide dna methylation microarray data (Illumina Inc)
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Genome Wide Dna Methylation Microarray Data, supplied by Illumina Inc, used in various techniques. Bioz Stars score: 97/100, based on 1721 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/dna+microarray+systems/iScan+System/bio_rxiv__2024__12__02__626017-43-0-14
Average 97 stars, based on 1721 article reviews
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1) Product Images from "Epigenetic investigation of multifocal small intestinal neuroendocrine tumours reveals accelerated ageing of tumours and epigenetic alteration of metabolic genes"
Article Title: Epigenetic investigation of multifocal small intestinal neuroendocrine tumours reveals accelerated ageing of tumours and epigenetic alteration of metabolic genes
Journal: bioRxiv
doi: 10.1101/2024.12.02.626017
Figure Legend Snippet: In this study, genome-wide DNA methylation of 100 samples from 11 patients was assessed. Each patient had multiple primary small intestinal neuroendocrine tumours (ranging from 2-16 per patient), and a subset of 9 patients had a matched normal small intestinal epithelial sample assessed. A subset of 8 patients also had metastases originating from their SI-NETs (ranging from 1-2 per patient). DNA methylation data was used to assess differential methylation relating to the multifocal tumours, the epigenetic clock was used to assess the ‘timing’ of tumour development and metabolic traits predicted by DNA methylation were compared between samples.
Techniques Used: Genome Wide, DNA Methylation Assay, Methylation
Figure Legend Snippet: (A) Plot of age predictions for normal epithelia samples (green), primary tumours (purple) and metastatic tumours (blue). Chronological age is indicated with the orange points and patients are indicated in order of chronological age. (B) Boxplot of age acceleration difference for the skin and blood clock predictions. (C) Somatic mutation count from tumours correlates with DNA methylation age in the skin and blood clock (p=0.0007).
Techniques Used: Mutagenesis, DNA Methylation Assay
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